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|CAS:||62-44-2||Types:||Pharmaceutical Raw Materials|
|Product Name:||Phenacet/ Fenacetina||Appearance:||White Or Similar Crystalline Powder|
|Usage:||Antipyretic Analgesics For The Treatment Of Fever, Headache, Neuralgia, Etc.||MF:||C10H13NO2|
99% Purity Pharmaceutical Intermediate Phenacetin For Fever Reducing CAS 62-44-02
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India. As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.
Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.
Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.
Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetis has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treatrheumatoid arthritis (subacute type) and intercostal neuralgia.
Phenacet/ Fenacetina Function:
Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting as aspirin,
low toxicity. Research shows that: This product and its metabolites acetaminophen have the antipyretic
effect. Because the enzyme inhibitor make phenacetins-Acetate not be converted into paracetamol, still showed
obvious antipyretic effect,thus the antipyretic effect after the product line not converrt to paracetamol.The
mild phenacetins-Acetate analgesic effect usually lasts 3 to 4 hours; and synergistic effect, of alicylic acid
coadministrationmake the analgesic effect enhancement. The main clinical is for small animal antipyretic analgesic. This product is also a component of the APC tablet.
|Test Items||Specification||Test Results|
|Description||Should comply with the standard||Pass|
|Identification||Should be positive reaction||Pass|
|P-Phenetidine||Brownish red 4#||Pass|
|4-chloroacetanilide||Should comply with standard||Pass|
|Melting point||134ºC to 137ºC||134ºC to 137ºC|
|Complies with BP68 edition|
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