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|Usage:||Bodybuilding||Type:||Pharmaceutical Raw Materials|
|Delivery:||By DHL, TNT, FedEx, HKEMS, UPS, Etc||Alias:||4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide|
Pharmaceutical Active Ingredients Pharmaceutical Raw Materials Avanafil CAS 330784-47-9
For most individuals, the recommended starting dose of avanafil is 100 mg per day taken about 30
minutes before sexual Avanafil activity. Depending on the adequacy of the response or side effects, the
dose may be increased to 200 mg or decreased to 50 mg a day. Individuals who are taking medications
that moderately increase Avanafil the blood levels of avanafil should not exceed a total dose of 50 mg in
24 hours.Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various
body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Other similar drugs are
sildenafil, tadalafil and vardenafil. The advantage of avanafil is that it has very fast on set of action
compared with other PDE5 inhibitors. It is absorbed quickly, reaching a maximum concentration in about
30–45 minutes. About two-thirds of the participants were able to engage in sexual activity within 15
|Residue on Ignition:||0.5%max||conforms|
|Solubility:||Almost insoluble in water, soluble in vegetable oil||Conforms|
|Specific optical rotation:||+28o～+35o||+33.4o|
1. Avanafil occurs as white crystalline powder, molecular formula C23H26ClN7O3 and molecular weight of
483.95 and is slightly soluble in ethanol, practically insoluble in water, and soluble in 0.1 mol/L
hydrochloric acid. for oral administration, is supplied as oval, pale yellow tablets containing 50 mg, 100
mg, or 200 mg avanafil debossed with dosage strengths.
2. Avanafil is a potent, highly selective phosphodiesterase 5 inhibitor, in vitro experiments showed that
the selectivity of phosphodiesterase 5 stronger than . The compound dear compliance weak against other
phosphodiesterase, and effect of adenosine receptor decreased, suggesting that the cardiovascular
effects of avanafil should be weaker than .
3. Pre clinical study showed that avanafil and organic nitrate drugs taken in combination to reduce its on
blood pressure was significantly weaker than and nitrate drugs with clothes. Moreover, avanafil inhibition
of phosphodiesterase 6 is very weak, the relevant visual disturbance suppression may the enzyme
phosphodiesterase 5 inhibitor induced and other.
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